Abstract:
Abstract: Neonatal sepsis remains a leading cause of neonatal morbidity and mortality in infant, especially
preterm and low birth weight baby. Sepsis is a clinical manifestation of a dysregulated immune response to
invasive pathogen.There is increasing evidence that Toll-like receptors (TLRs) play a key role in the mediation
of systemic responses to invading pathogens during sepsis. TLRs are essential for triggering the host’s immune
response, acting as a sensor against invading pathogens. TLR2 was identified as a receptor for gram-positive
peptidoglycan and bacterial lipopeptides, whereas TLR4 is part of a receptor complex recognizing gramnegative
bacterial.
Saliva is an important body fluid for detecting the physiological and pathological situations of the
human body. Neutrophils are considered to participate in the acute response against pathogens in many tissues,
and influx into the oral cavity occurs at any time. The expression and function of TLRs greatly influence the
quality and control of innate immune response in patients with infectious disease. The high expression of TLRs
and phagocytic activity of neutrophil saliva upon presentation of early onset neonatal sepsis patients, suggests
this parameter as potential early sepsis biomarker.
