Artikel : Toll-like Receptor 2 , Toll-like Receptor 4 Expression and Phagocytic Activity of Neutrophil in Saliva of New Born Babies With Sepsis Risk, An Early Detection Of Neonatal Sepsis

Abstract

Abstract: Neonatal sepsis remains a leading cause of neonatal morbidity and mortality in infant, especially preterm and low birth weight baby. Sepsis is a clinical manifestation of a dysregulated immune response to invasive pathogen.There is increasing evidence that Toll-like receptors (TLRs) play a key role in the mediation of systemic responses to invading pathogens during sepsis. TLRs are essential for triggering the host’s immune response, acting as a sensor against invading pathogens. TLR2 was identified as a receptor for gram-positive peptidoglycan and bacterial lipopeptides, whereas TLR4 is part of a receptor complex recognizing gramnegative bacterial. Saliva is an important body fluid for detecting the physiological and pathological situations of the human body. Neutrophils are considered to participate in the acute response against pathogens in many tissues, and influx into the oral cavity occurs at any time. The expression and function of TLRs greatly influence the quality and control of innate immune response in patients with infectious disease. The high expression of TLRs and phagocytic activity of neutrophil saliva upon presentation of early onset neonatal sepsis patients, suggests this parameter as potential early sepsis biomarker.