Formulation of herbal Pills of Stenochlaena palustris: An overview of fineness variations of powders, concentration of dissintegrant, and drying time

Abstract

This study aims to determine the effects of fineness variations of powder, concentration of disintegrant and the drying time on uniformity of weight and time. Herbs powder formulation of kelakai pills use subtle variations in the degree of powder with a sieve number 60, 80, and 100, manihot starch concentration 3%, 4%, 5% as a dissintegrant. Mucilago amili by 10% as the concentration of material binding, aquadest and 5 % glycerin as a wetting agent, and lactose as fillers. Dried at a temperature of 45oC with drying time 4, 5 and 6 hours. Test results were analyzed statistically with the Kolmogorov-Smirnov to detemine the distribution of the data (P<0,05) means is not normal and normality (P>0,05) is homogeneous, followed by analysis using non-parametric Kruskal Wallis test an Mann Whitney Test. The best formula is the formula of the type A1 fine powder 60 degrees with concentration amylum manihot 3% as a destroyer with a 4 hours drying time in which the weight unformity test average showed noaberrant 2 pills 10% of the average weight and none of the pills that deviate 20% from the average weight. When crushed the average of 6 hours drying approximately 60 minute.