THE ROLE OF ATORVASTATIN AS BRAIN PROTECTOR IN MODERATE TRAUMATIC BRAIN INJURY PATIENTS MEASURED BY TISSUE PLASMINOGEN ACTIVATOR AND GCS SCORE IMPROVEMENT RATE

Abstract

Traumatic brain injury (TBI) still stands as a major morbidity and mortality problem in the world. Priority of management is to prevent secondary brain injury which can make worse the outcome. Neuropharmacology is one method in brain protection to prevent secondary brain injury. Statin had a cholesterol-independent pleiotropic effect with potential effects in the management of neurological disorders such as reducing the effects of thrombosis, coagulation and anti-inflammatory cascade. The aim of this study was to examine the effect of oral atorvastatin 40 mg toward levels of tPA, and the rate of improvement of GCS score of patients with moderate TBI.