Riam Kanan belonging classified as large watersheed in South Kalimantan and until now receiving enormous pressure from anthropogenic activities, mainly for cages, fish farmers, raw water, agriculture and households. But it has not quantified scientifically based on scale of space and time. The aim of this study was to analyze the types of anthropogenic activities that potentially interfere biological function of Riam Kanan watersheed, and to create model formulation effect of anthropogenic activities using Vensim PLE. The field data were obtained for potential disturbance impacts between spatial and time scales and quantify disturbance effect on evidence of water hyacinth plants. We examine how four parameter key anthropogenic disturbances in Riam Kanan watersheed can be formulated and modeled at the watershed scale, for sustainable utilization in Riam Kanan. Results showed that household activities, cages, and sand mining are the most anthropogenic activities that disrupt biological functions Riam Kanan watersheed. Model formulation successfully formulated the concept that fish farmers incomes will be increased from floating net cages and sand excavation, but it must reduced by the cost for clean water and health facilities. Further research is looking for how to balance anthropogenic needs according to Riam Kanan watersheed carrying capacity. Key words : activities, anthropogenic, wetland, riam kanan, watersheed