Abstract:
Introduction: Hirschsprung’s disease-associated
enterocolitis (HAEC) remains a substantial morbidity and
mortality risk in Hirschsprung's disease. HAEC is a
challenge. Its p athophysiology is still a mystery, and no
adequate treatment strategy exists. The aim of the study is
to analyse the pre-and post-operative, mortality and
complications: strictures, anastomotic leak, constipation
and incontinence associated with HAEC.
Materials and Methods: Adjust to the Preferred Reporting
Items for Systematic Review and Meta-Analysis (PRISMA)
2020; this study met all the requirements and was up-todate.
The search approach was online publications between
2013 and 2023 in Pubmed and SagePub. It was decided not
to consider review pieces that had already been published
and half done. The STATA 18th version was used for metaanalysis.
Results: Our search results included 370 PubMed and 149
SagePub articles. Since 2013, 134 PubMed and nine
SagePub articles have been obtained, and seven studies
have met the criteria.
Conclusion: Disorders of intestinal motility in the
aganglionic segment and accumulation of faeces disrupt the
balanced microbiota population, which are factors of preoperative
HAEC. Major congenital anomalies and low birth
weight worsen pre-operative HAEC. Pre-operative HAEC can
continue and affect the post-operative. Constipation and
fecal incontinence are still the main challenges after HSCR
surgery.
