Abstract:
Bruguiera gymnorrhizais one of the mangrove species that a source of antioxidants.Antioxidant substances are able to protect cells from oxidative stress and other related diseases. This study aimed to evaluate the chemical profiles, predicted biological activity,
and antioxidant activity of theB. gymnorizafruit extracts. The research methods included sampling, extraction (maceration with MeOH:DCM), identification of chemical profiles (GCMS spectra analysis), assaying for computational analysis (PASS server and
ADMET), antioxidants (DPPH radical scavenging), and total phenolic content (Folin-Ciocalteu).Bruguiera gymnorrhizafruits was collected from Central Sulawesi, Indonesia.The chemical profiles detected in theB. gymnorrhizafruit extracts, namely
isopimaradiene (64.20%); 4-(2-Aminopropyl) phenol (19.06%); dimethylamino-
dimethylphosphene oxide (9.40%); 3-amino-2-benzylbutanoic acid (5.46%); and 1,4-dideuteriooctane (1.89%). PASS server analysis showed that the five compounds detected
fromB. gymnorrhizafruit have the potential as an NF-E2-related factor (Nrf2) stimulant and oxygen scavenger. The ADMET analysis results indicated thatB. gymnorrhizafruits could be developed as folk medicine and nutraceutical products.
