Abstract:
Background: Polycystic ovary syndrome (PCOS) is a global health concern for women in reproductive
age women. Numerous studies have been reported an association between chronic inflammation and
alteration of cytokine in women with PCOS. Syzygium polyanthum (S. polyanthum) contains antioxidants
and has antiinflammation activity. Objectives: This study aims to measure the alteration of IL-6, BMP-15,
and GDF-9 in rat PCOS model after treated with S. polyanthum leaves extract. Materials and Methods:
The female Wistar rats were divided into five groups (n = 5), K0 (normal control), K1 (PCOS group),
and three treatment groups which received three different doses of S. polyanthum leaves extract. The
treatment group consisted of PCOS rat models with S. polyanthum leaves extract supplementation of
150 mg/KgBW (P1), 300 mg/KgBW (P2), and 450 mg/KgBW (P3). Results: IL-6 expression was highest
in K1 (4,690 ± 0.099) and lowest in the P3 treatment, namely (2,370 ± 0.105). The expression of BMP-15
and GDF-9 was lowest at K1 (2.554 ± 0.04; 4.502 ± 0.050) and highest at P3, namely (2.265 ± 0.072;
4.736±0.074). Conclusion: S. polyanthum leaves extract was significantly effective in decreasing IL-6
expressions, as well as a significant increase in BMP-15 and GDF-9 expressions in the PCOS rat model.
