Abstract:
Background: The ethanol extract of binjai leaves contains bioactive compounds that are saponin, tannin,
triterpenoid, steroid, alkaloid and flavonoid which potentially as an anti-inflammation, anti-bacterial,
and antioxidant. It can fasten and control the process of scar healing. The binjai leaves extract was made
into gel preparation. The binjai leaves extract gel can affect fibroblast cell number during the
proliferation phase. Purpose: To analyze the effect of binjai (Mangifera caesia) leaves extract gel to the
fibroblast cell number on male wistar rats (Rattus norvegicus) incision wound. Methods: This research
design was a true laboratory experimental research with post-test only with control group design which
used 24 male wistar rats and divided into 4 groups: the negative control group that was given the placebo
gel and the treatment group that was given the binjai leaves extract gel with 5%, 10%, and 15%
concentrations. Results: The result of Two-way ANOVA statistic test shows that there is a meaningful
difference in the treatment group on the 7th day (p=0,000) and on the 14th day (p=0,000). The Post-Hoc
Bonferroni test for fibroblast cell number on the 7th and 14th day shows that there is a meaningful
difference (p<0,05) between the negative control group and the treatment group. Conclusion: Binjai
leaves extract gel have an effect to the fibroblast cell number on male wistar rats incision wound with the
most effective concentration of 15%
