Abstract:
Binjai (Mangifera caesia) leaves extract contains flavonoid, saponin, phenolic, tannin,
alkaloid and triterpenoid. The said contents are known to help the process of wound healing. Gel
formations contains a lot of water, resulting in substance penetration into the tissue will be better if used
as wound healing adjuvant therapy. Purpose: To analyze the effect of binjai leaves extract gel (Mangifera
caesia) that topically given to collagen fiber density on the wistar rat incision wound. Methods: This
research was a true experimental with post test only with control group design that consists of 4 groups.
Group I has been given the placebo gel as control, group II, III and IV have been given the binjai leaves
extract gel with 5%, 10% and 15% concentration that observed on the 7th day and 14th day. The
collagen fiber density assessed by measuring hydroxyproline with Stegmann and Stalder method. Results:
The research result shows that the 15% concentration of binjai leaves extract gel has a better effect on
collagen fiber density compared to 5% and 10% concentrations. Two-way Anova data analysis revealed
that the significant difference average of collagen fiber density of the whole group with the value of sig.p
< 0,05. Conclusion: The 15% concentration of binjai leaves extract gel has the most optimal effect
compared with the 5% and 10% concentrations to collagen fiber density on the wistar rat incision wound.
