Abstract:
This study aims to determine the influence of fine degrees of variation powders, the
concentration of dissinegrant and drying time of the test uniformity of weight and disintegration time in order to produce a good supply of pills. Herb powder formulation pills kelakai using variation of the degree of fine powder with the sieve numbers 60, 80 and 100, starch concentration Manihot 3%, 4%, 5% as a dissintegrant, Mucilago amili with 10% concentration as a binder, 5% distilled water and glycerin as a wetting materials, as well as lactose as filler. Dried at a temperature of 45oC with time drying four, five and six hours. The test results were analyzed statistically with kolmogorov-smirnov to know the data distribution (P <0.05) means that no normal and normality (P> 0.05) means homogeneous, followed by non-analyzing using parametric Kruskal Wallis test and Mann whitney. Formula. The best is the formula A1 with a type of fine powder of 60 degrees, Manihot amylum with 3% concentration with time as dissintegrant 4 hours of drying, where the uniformity of the test results showed an average weight there are no two pills
that deviate 10% from the average weight and none of the pills deviates 20% from the average weight. The average disintegration time of drying hours to 4, 5, and to six or less more than 60 minutes.
