Abstract:
Plants produce a variety of secondary metabolites, one of
which is essential oils that contain a variety of volatile compounds and
are useful for humans. Cymbopogon nardus contains volatile compounds
that can inhibit the proliferation of cancer cells. This research aims to
explore the antiproliferation activity of C.nardus’ essential oils with
different concentrations against breast cancer Michigan Cancer
Foundation-7 (MCF-7) cells. Antiproliferation test was carried out with
total cells method using trypan blue and cells were calculated using a
microscope. Gas Chromatography-Mass Spectrometer (GC-MS) was
performed to identify the volatile compounds. The results showed that
the Inhibitory Concentration 50 (IC50) value was 359.6 ppm with an
inhibition percent of 44.49% at 170 ppm. Meanwhile, inhibition percent
against Vero normal cell was 29.04%, compared to Doxorubicin 35.23%.
The dominant volatile compound in C. nardus’ essential oil were
Geraniol and Citronellol.
