Abstract:
Background: Karamunting leaf is a wetland herb with antioxidant
compounds that bind free radicals, reduce oxidative stress, reduce insulin
resistance, and prevent the development of pancreatic cell dysfunction
and damage.
Objective: This study aims to prove the antidiabetic potential of the
karamunting leaves ethanolic extract in treating diabetes in white male
rats.
Methods: This study used a true experimental with a pre-test and posttest control group design. Thirty rats were divided into four groups
(control: C, ethanol extract of karamunting dose of 100 mg: P1, 200 mg:
P2, and 400 mg: P3). Data on fasting blood glucose levels were taken
before (pre-test) and after treatment (post-test). Data on pancreatic
islets histomorphological changes (size, number, constituent cells) were
analysed quantitatively. Fasting blood glucose levels were analysed using
paired t-test, while the histomorphological data of the pancreatic islets
were analysed using ANOVA. The data were considered significant if the
p-value <0.05 (95% CI).
Results: Karamunting leaf ethanol extract treatment reduced fasting blood
glucose levels in diabetic rats. A 200 mg/kgBW was demonstrated as the
most effective dose that improves the islets and cells number compiles the
pancreatic islets, potentially treating diabetes mellitus (DM).
Conclusion: Karamunting leaf ethanol extract potential as a natural
herbal medicine in treating DM.
Keywords:
diabetes mellitus,
karamunting leaves,
pancreatic islets
