Diabetes is a chronic metabolic disease with signs of increased blood
glucose levels. Type 2 diabetes is common diabetes in adults. Bawang
dayak is one of the plants believed to have the efficacy of curing
various types of diseases. The purpose of this study was to find out
the comparison of hypoglycemic effects between combinations of
bawang dayak extract and acarbose with single acarbose. This study
was an experimental study using 32 white mice divided into two
groups. Group one was given a combination of bawang dayak at a
dose of 100 mg/kg BW and acarbose at a dose of 40 mg/100 g BW,
while group two was given acarbose at a dose of 40 mg/100 g BW.
Treatment is administered after the test animal is induced with
dexamethasone at a 1 mg/kg BW dose dissolved in NaCl 0.9%
subcutaneously for 12 days. Measurement of glucose levels was
carried out using a glucometer. Data retrieval was carried out every
three days for 15 days after previously fulfilled for +10 hours. Blood
glucose level data were analyzed with the General Linear Model test.
The combination of bawang dayak-acarbose onion extract had a
greater decrease in blood glucose levels than single acarbose. Average
reduction in blood glucose levels for D+3; D+6; D+9; D+12; and D+15
was 187.31; 168.56; 140.81; 119.81; and 102.56 mg/dl, respectively. The
General Linear Model test results showed a p <0.05 value that
significantly impacted blood glucose levels between groups.
Received: September 30th, 2020
Accepted: April 1st, 2021
Published: May 30th, 2021
Diabetes is a chronic metabolic disease with signs of increased blood
glucose levels. Type 2 diabetes is common diabetes in adults. Bawang
dayak is one of the plants believed to have the efficacy of curing
various types of diseases. The purpose of this study was to find out
the comparison of hypoglycemic effects between combinations of
bawang dayak extract and acarbose with single acarbose. This study
was an experimental study using 32 white mice divided into two
groups. Group one was given a combination of bawang dayak at a
dose of 100 mg/kg BW and acarbose at a dose of 40 mg/100 g BW,
while group two was given acarbose at a dose of 40 mg/100 g BW.
Treatment is administered after the test animal is induced with
dexamethasone at a 1 mg/kg BW dose dissolved in NaCl 0.9%
subcutaneously for 12 days. Measurement of glucose levels was
carried out using a glucometer. Data retrieval was carried out every
three days for 15 days after previously fulfilled for +10 hours. Blood
glucose level data were analyzed with the General Linear Model test.
The combination of bawang dayak-acarbose onion extract had a
greater decrease in blood glucose levels than single acarbose. Average
reduction in blood glucose levels for D+3; D+6; D+9; D+12; and D+15
was 187.31; 168.56; 140.81; 119.81; and 102.56 mg/dl, respectively. The
General Linear Model test results showed a p <0.05 value that
significantly impacted blood glucose levels between groups.
Received: September 30th, 2020
Accepted: April 1st, 2021
Published: May 30th, 2021
Keywords:
Acarbose
Bawang dayak
Glucose levels
Diabetes is a chronic metabolic disease with signs of increased blood
glucose levels. Type 2 diabetes is common diabetes in adults. Bawang
dayak is one of the plants believed to have the efficacy of curing
various types of diseases. The purpose of this study was to find out
the comparison of hypoglycemic effects between combinations of
bawang dayak extract and acarbose with single acarbose. This study
was an experimental study using 32 white mice divided into two
groups. Group one was given a combination of bawang dayak at a
dose of 100 mg/kg BW and acarbose at a dose of 40 mg/100 g BW,
while group two was given acarbose at a dose of 40 mg/100 g BW.
Treatment is administered after the test animal is induced with
dexamethasone at a 1 mg/kg BW dose dissolved in NaCl 0.9%
subcutaneously for 12 days. Measurement of glucose levels was
carried out using a glucometer. Data retrieval was carried out every
three days for 15 days after previously fulfilled for +10 hours. Blood
glucose level data were analyzed with the General Linear Model test.
The combination of bawang dayak-acarbose onion extract had a
greater decrease in blood glucose levels than single acarbose. Average
reduction in blood glucose levels for D+3; D+6; D+9; D+12; and D+15
was 187.31; 168.56; 140.81; 119.81; and 102.56 mg/dl, respectively. The
General Linear Model test results showed a p <0.05 value that
significantly impacted blood glucose levels between groups.
Received: September 30th, 2020
Accepted: April 1st, 2021
Published: May 30th, 2021
Diabetes is a chronic metabolic disease with signs of increased blood
glucose levels. Type 2 diabetes is common diabetes in adults. Bawang
dayak is one of the plants believed to have the efficacy of curing
various types of diseases. The purpose of this study was to find out
the comparison of hypoglycemic effects between combinations of
bawang dayak extract and acarbose with single acarbose. This study
was an experimental study using 32 white mice divided into two
groups. Group one was given a combination of bawang dayak at a
dose of 100 mg/kg BW and acarbose at a dose of 40 mg/100 g BW,
while group two was given acarbose at a dose of 40 mg/100 g BW.
Treatment is administered after the test animal is induced with
dexamethasone at a 1 mg/kg BW dose dissolved in NaCl 0.9%
subcutaneously for 12 days. Measurement of glucose levels was
carried out using a glucometer. Data retrieval was carried out every
three days for 15 days after previously fulfilled for +10 hours. Blood
glucose level data were analyzed with the General Linear Model test.
The combination of bawang dayak-acarbose onion extract had a
greater decrease in blood glucose levels than single acarbose. Average
reduction in blood glucose levels for D+3; D+6; D+9; D+12; and D+15
was 187.31; 168.56; 140.81; 119.81; and 102.56 mg/dl, respectively. The
General Linear Model test results showed a p <0.05 value that
significantly impacted blood glucose levels between groups.
Received: September 30th, 2020
Accepted: April 1st, 2021
Published: May 30th, 2021
Keywords:
Acarbose
Bawang dayak
Glucose levels
