Abstract:
BACKGROUND: Mangosteen (Garcinia mangostana L.) is a plant that contains
various secondary metabolite compounds, one of which is xanthone. Xanthone in
mangosteen has a variety of beneficial biological and medical effects, one of which is
an antioxidative, anti-inflammatory, and antiapoptotic agent. AIM: The aim of the study was to perform the selection of any xanthone in
mangosteen pericarp that have potentially inhibit the interaction of AGEs and RAGE. METHODS: The analysis was made in silico by docking method using software Hex
8.0. The docking was done between AGEs-RAGE, also between nine active
compounds of G. mangostana with RAGE. The active compounds analyzed here
were including α-mangostin, β-mangostin, γ-mangostin, mangostanol, garcinone D, 1,6-Dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)-xanthone, gartanin, 1-isomangostin, and 3-isomangostin. Further analysis was performed to see the
interactions formed between ligands with their receptors using software LigPlus+ and
Discovery Studio 4.1.
RESULTS: 1-isomangostin, 3-isomangostin, γ-mangostin, mangostanol, D-garcinone, and gartanin have potentially could inhibit the interaction and activity of imidazole in
RAGE through a competitive binding mechanism. CONCLUSIONS: The inhibition of imidazole-RAGE activity by the mangosteen active
components may inhibit the pathobiology of AGEs-RAGE axis
