Abstract:
Epidemiological evidence suggested the relationship between
pesticide exposure and increased risk of autism. In autism, there is
a change in the production of neurotransmitters and oxidative
stress. Seluang fish has high-protein that has not been investigated
for its effects on autism. This study aimed to determine the effect
of seluang fish on neurotransmitters and oxidative stress in
endosulfan-induced rats intrauterine. This study used pup's rat
induced by endosulfan intrauterine. The pregnant rats divided into
2 groups were K0 without endosulfan induced and K1 with
endosulfan induced. After 4 weeks, 8 pup's rats of K0 and K1 were
sacrificed for blood and brain samples, while 8 pup's rats were
given a standard diet (P1) and fed a Seluang fish diet (P2)
respectively for 4 weeks. Then examined the parameters of serum
and brain serotonin, brain H2O2, SOD, and MDA levels. The results
showed that K1had increased brain H2O2 and MDA levels, whereas
brain and serum serotonin levels and brain SOD decreased
significantly compared to K0. Group P1 and P2 showed decreasing
brain H2O2 and MDA levels significantly than K1, brain serotonin
levels increased significantly than K1, whereas serum serotonin
