Abstract:
Preeclampsia is a condition which was identified by diastol blood pressure ≥ 90 mmHg in 20 weeks
of pregnant, and blood pressure in < 20 weeks of pregnant was still < 90 mmHg. Beside
hypertension, we also find proteinuria in preeclampsia after 20 weeks of pregnant. Preeclampsia
could cause low renal function that was indicated by creatinine and UACR level. Preeclampsia
happened from endothelial dysfunction. Endothelial dysfunction in Mus musculus could be made by
injecting anti QA2. This research was to analyze urine protein, creatinine, and UACR level in
endthelial dysfunction model in pregnant Mus musculus. The result was dose of anti QA2 could
cause the increasing of urine protein and UACR level, but not to urine creatinine level. The
conclusions were there was significant differences of urine and UACR protein level in pregnant Mus
musculus that was injected by anti QA an endothel dysfunction model that induced preeclampsia, but
not to urine creatinine level. The suggestions were preeclampsia must be detected, prevented and
treated as soos as possible, to prevent mechanism of endothel dysfuncyion in preeclampsia that could
cause low renal function.
