Abstract Intensive exercise can induce pro and anti-inflammatory cytokines, which is clearly seen with an increase in leukocytes in the circulation.DAMPs trigger massive cytokine release including tumor necrosis factor (TNF-α), interleukin (IL) -1, IL-6, IL-8, IL-12 and IFN types I and II. HMGB1 in human monocyte culture stimulates the release of some TNF-α, IL-1, IL-6, IL-8 and inflammatory protein macrophages (MIP)-1.Exercise can cause a high inflammatory response by increasing proinflammatory and anti-inflammatory cytokines (IL6, IL8, IL10, IL1β, and TNFα). In Men IL1β and TNF-αhigher levels than women, both at baseline values and on the results of the examination after exercise. Exercise with an exercise program can increase IFN, TNF levels-α, IL-6, IL-8, IL1β, VEGF and MCP. In aerobic exercise there were no significant changes in TNF levels-αand IL-6 but there is an increase in the number of neutrophils. Intensity and aerobic exercise in experimental animals increased TNF levels-αand IL-6 in High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) while in short-term aerobic exercise the HMGB1 level decreased. Conclusion: Exercise can affect DAMPs, HMGB1, proinflammatory cytokines, and blood leukocytes depending on variation, duration, intensity, type of exercise, and research subjects. Key words: Hmgb1, Proinflammatory Cytokines, Leukocytes