The phenomenal growth of e-learning in the developed countries makes Indonesia going with the trend by investing massively in Information Technology and Communication (ICT) to push the country into a knowledge economy. However, e-learning – as the implementation of ICT in higher education - is not without challenges and failures as the technology cannot be perceived as a panacea. Many researchers and practitioners have acknowledged that e-learning as a future prospective medium of instruction encounters difficulties and challenges to implement successfully. The objective of study is to investigate the influential adoption factors to adopt new technologies drawn from recent technology adoption theories. Further, the present study examines the moderating impact of one Hofstede’s national culture dimensions (individualism-collectivism) toward adoption factors in adopting e-learning technology. The empirical data, which consists of 200 valid datasets, were collected from lecturers in Indonesia via self-administered paper-based questionnaire, and Structural Equation Modeling (SEM) was employed. The finding of this research advances our understanding of the dynamics of e-learning technologies and refines existing conclusions about perspectives of educators towards the adoption process of e-learning technologies. Further, the current gap between developed and developing countries on the effects of cultural dimensions provide an original reference on how the culture side influences the individuals’ behaviors when adopting new technology. Key words: E-learning, culture, technology acceptance, Indonesia