Damage to spinal cord and its subsequent neurological deficits have been recognized as the complications of scoliosis repair surgery. Wake up test has been a safe, simple and reliable method to recognize such complications. Dexmedetomidine and Sevoflurane were the main anaesthetics for a 14 year old girl who underwent a scoliosis repair surgery with the intra operative wake-up test and hemodynamic stability. The analgesic property of Dexmedetomidine was complemented by the continuous Fentanyl infusion. Dexmedetomidine, Sevoflurane and continuous Fentanyl infusions were administered to achieve the maintenance of the anesthesia. These anaesthetic regimens produced a satisfactory result for the intra operative hemodynamic stability and the wake-up test with the minimum complication. Here, a case of scoliotic repair surgery was presented using Dexmetomidine, Sevoflurane and Fentanyl infusion as the safe anaesthetic regimens. Key words: Dexmedetomidine, Fentany, Scoliosis, Wake up Test.