The fire problem still happened at everywhere. It shows that is very necessary a precautions against fire needs to be improved, one by providing a fire extinguisher. It is required knowledge and attitudes, especially for a wife to provide and use a fire extinguisher if necessary at any time. The research objective was to determine the relationship between knowledge and attitudes house wife to fire prevention efforts by fire extinguisher at home preparation. This research method is analytical observation with cross sectional design. The population in this study amounted to 189 people, with a purposive sampling technique obtain a sample of 100 respondents. The results using the chi square test showed no correlation between housewives knowledge with fire prevention efforts with fire extinguisher preparation at home with p-values of 0.021 and there is a correlation knowledge housewife with fire prevention efforts with fire extinguisher preparation at home with a p-value of 0.011. Based on these results, society especially housewives expected more alert to the danger of fire by setting fire extinguisher in the house. Keywords: knowledge, attitude, OHS fire, fire extinguisher