The river plays a vital role in the daily life of the Banjarese people, Indonesia. Unfortunately, the awareness of the people to keep the rivers clean is still lacking. Hence, the number of rivers in Banjarmasin is decreasing, and the water quality is getting poorer. The study aimed to improve students’ awareness of river environment and science process skills by designing learning strategies integrating four subjects, namely: Science, Indonesian language, English, and Civics education. This research employed Research and Development with the 4-D model. The pilot study of the learning design was administered for 100 junior high school students. The data were collected by questionnaires and a science process skill test and were analyzed using descriptive analysis. The results showed that the integrated learning strategy developed in this research was valid, practical, and effective to develop students’ awareness of river environment and science process skills. Four weeks after the learning was completed, students’ awareness of river environment remains high. Students’ process skills of observing, collecting data, and concluding developed higher compared to other skills. Further research is needed to provide more evidence by implementing the strategy involving other subjects.