ABSTRACT Cyanide is one of the rapid acting poisons. Exposure to cyanide can cause several health problems, including liver cells damaged. However, the mechanism of liver cells damage by cyanide still not clear. In this present study, we proposed that cyanide could induced liver cells damaged via oxidative and chlorinative stress pathway. Thus, our study aimed to investigated the effect of cyanide on liver cells via oxidative and chlorinative stress pathway by measuring the levels of hydrogen peroxide (H2O2) malondialdehyde (MDA), Advanced Oxidation Protein Products (AOPPs), the myeloperoxidase (MPO) acivity, and the chlorinative index (CI). The results revealed that cyanide exposure positively correlated with H2O2, MDA, AOPPs level, and CI, and negatively correlated with MPO activity in liver cells homogenate. These results indicated that cyanide exposure induce liver cells damage through the oxidative and chlorinative stress pathway which can be seen from the correlation between cyanide exposure and the levels of H2O2, MDA, and AOPPs, the activity of MPO, and the CI. Keywords: Chlorinative Stress, Cyanide, Oxidative Stress