| dc.creator |
KANIA, NIA |
|
| dc.creator |
Thalib, Iskandar |
|
| dc.creator |
Suhartono, Eko |
|
| dc.date |
2016 |
|
| dc.date.accessioned |
2020-06-15T03:57:24Z |
|
| dc.date.available |
2020-06-15T03:57:24Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/1427/1/IJPCR%2CVol8%2CIssue9%2CArticle7.pdf |
|
| dc.identifier |
http://eprints.ulm.ac.id/1427/7/08.%20Chlorinative%20index%20in%20liver%20toxicity%20induced%20by%20iron.pdf |
|
| dc.identifier |
KANIA, NIA and Thalib, Iskandar and Suhartono, Eko (2016) Chlorinative Index in Liver Toxicity Induced by Iron. Chlorinative Index in Liver Toxicity Induced by Iron, 8 (9). ISSN 0975-1556 |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/9995 |
|
| dc.description |
Iron (Fe) is a metal that is present in high concentrations in coal dust. Exposure to coal dust could increase the
concentration of Fe in the body and can cause several health problems, including liver cells damaged. However, the
mechanism of liver cell damage by Fe in the coal dust is still not clear. In this present study, we proposed that Fe could
induced liver cells damaged via chlorinative stress pathway. Thus, our study aimed to investigated the effect of Fe on
liver cells via chlorinative stress pathway by measuring the levels of hydrogen peroxide (H2O2) and Advanced Oxidation
Protein Products (AOPPs), the myeloperoxidase (MPO) acivity, and chlorinative index (CI). The results revealed that Fe
exposure could significantly increased H2O2 and AOPPs level, and CI in liver cells (P<0.05). The result also revealed that
Fe exposure could decreased the MPO activity but non-statistically significant (P>0.05). These results indicated that Fe
exposure induce chlorinative stress which can be seen from the increasing of H2O2 and AOPPs levels, and CI. However,
the exact mechanism of Fe induced the chlorinative stress is still unclear yet, because the MPO activity did not
statistically changed. Further study may be needed to determine the Fe mechanism to induce chlorinative stress. |
|
| dc.format |
text |
|
| dc.format |
text |
|
| dc.publisher |
IJPCR |
|
| dc.relation |
http://impactfactor.org/PDF/IJPCR/8/IJPCR,Vol8,Issue9,Article7.pdf |
|
| dc.relation |
http://eprints.ulm.ac.id/1427/ |
|
| dc.subject |
R Medicine (General) |
|
| dc.title |
Chlorinative Index in Liver Toxicity Induced by Iron |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|