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ABSTRACT
The objectives of this study were to determine the protective effect of quercetin on NSAIDs-induced gastric mucosal
damage by measuring the level of superoxide radical, hydrogen peroxide (H2O2), protein carbonylation (PC), and
advanced oxidation protein products (AOPPs). In this experiment, a gastric mucosa was taken from male rats (Rattus
novergicus). Samples then homogenized and divided into three groups with; T1 served as control which contains gastric
mucosa homogenate only; T2 which contains gastric mucosa homogenate + 500 mg of mefenamic acid; and T3 which
contains gastric mucosa homogenate + 500 mg of mefenamic acid + 250 mg/L of quercetin. After treatment, every 15-
minute superoxide radical, H2O2, PC, and AOPPs levels were estimated. The results revealed that mefenamic acid
increased the rate of superoxide radical, H2O2, PC, and AOPPs formation, while quercetin decreases the rate of all
parameters. These results indicated that mefenamic acid induce gastric mucosal damage through oxidative stress and
inflammation mechanisms as can be seen from the increasing of superoxide radical, H2O2, PC, and AOPPs levels. Also,
the results indicated that quercetin have a protective effect to gastric mucosa as can be seen from the decreasing of all
parameters.
Keywords: Gastric Mucosal Damage, Inflammation, Mefenamic Acid, Oxidative Stress, Quercetin |
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