| dc.creator |
Fitriana, Mia |
|
| dc.date.accessioned |
2020-06-15T03:57:21Z |
|
| dc.date.available |
2020-06-15T03:57:21Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/1423/1/Mia_Fitriana_Abstract_ISPST_%281%29.pdf |
|
| dc.identifier |
Fitriana, Mia FORMULATION AND CHARACTERIZATION OF MICROEMULSION BASED GEL CONTAINING Mangifera casturi Konsterm. FRUCTUS EXTRACT. FORMULATION AND CHARACTERIZATION OF MICROEMULSION BASED GEL CONTAINING Mangifera casturi Konsterm. FRUCTUS EXTRACT. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/9970 |
|
| dc.description |
Mangifera casturi fructus extract has potential antioxidant activity and potential
treatment of various diseases associated with free radicals. This extract has to be
formulated in microemulsion dosage form to increase the stability and to help its
penetration through human skin. Microemulsion as topical delivery is
incorporated in gel base to prolong the local contact to the skin. The purpose of
this study was to develop microemulsion based gel formulation for topical delivery
of Mangifera casturi fructus extract. Surfactant and co-surfactant concentrations
were optimized and pseudoternary diagram was prepared by water titration
method. The microemusions were characterized and incorporated with gel
polymer to increase the viscosity. The microemulsion based gel was evaluated by
its homogeneity, viscosity, pH, adhesion, and spreadability measurement. The
results showed that optimum microemulsion formula was contain 1.96%w/w
Virgin Coconut Oil as oil base, 15.68%w/w polysorbate 80 as surfactant, and
1.96%w/w sorbitol as co-surfactant. This formula had clear, yellowish color and
odorless organoleptic. The average globule size was 4.231±0.308 µm, the type of
microemulsion was oil in water, pH value was 7.68±0.07 and the viscosity was
218.75 cPs. The microemulsion was stable with centrifugation test. HPMC as a gel
matrix was chosen to construct the microemulsion based gel containing Mangifera
casturi fructus extract. The microemulsion based gel showed good physical
characteristics and indicate a promising topical delivery of Mangifera casturi
fructus Extract.
Keywords: Mangifera casturi, microemulsion, gel |
|
| dc.format |
text |
|
| dc.relation |
http://farmasi.unpad.ac.id/ispst2016/ |
|
| dc.relation |
http://eprints.ulm.ac.id/1423/ |
|
| dc.subject |
RS Pharmacy and materia medica |
|
| dc.title |
FORMULATION AND CHARACTERIZATION OF MICROEMULSION
BASED GEL CONTAINING Mangifera casturi Konsterm. FRUCTUS EXTRACT |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|