| dc.creator |
Sari, Destria Indah |
|
| dc.date.accessioned |
2020-06-15T03:57:18Z |
|
| dc.date.available |
2020-06-15T03:57:18Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/1412/1/Abstract_ISPST.pdf |
|
| dc.identifier |
Sari, Destria Indah EFFECT OF GINGER OIL IN DICLOFENAC SODIUM CREAM TO PREPARATION PHYSICAL CHARACTERIZATION, SYSTEM STABILITY, ANTIINFLAMMATORY ACTIVITY AND IRRITATION. EFFECT OF GINGER OIL IN DICLOFENAC SODIUM CREAM TO PREPARATION PHYSICAL CHARACTERIZATION, SYSTEM STABILITY, ANTIINFLAMMATORY ACTIVITY AND IRRITATION. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/9942 |
|
| dc.description |
ABSTRACT
Diclofenac sodium is a lipophilic non-selective NSAID which has difficulties to
penetrate due to its binding to high lipid content of stratum corneum. The addition of
penetration enhancers in diclofenac sodium topical preparation needed to increase
drug bioavailibility. Essential oil, such as ginger oil, is chemical penetration enhancer
which considerably safe and has low irritation effect. This study was aimed to
determine effect of ginger oil to preparation physical characterization, system stability,
inflammatory effect, and irritation caused by application. Diclofenac sodium cream
were made by varying ginger oil concentrations (1%, 3% and 5%). Another three
formulas were also made to compare with preparation earlier stated, those were cream
without ginger oil, 5% ginger oil cream without active ingredient, and cream without
ginger oil and active ingredient. Physical characterization were observed on
organoleptic, viscosity, spreadability, and adhesion time. System stability were
observed on phase separation after centrifuged 10.000 rpm for 30 minutes.
Antiinflammatory effect were evaluated on six groups of 5 male Wistar rats injected
with 0.4 mL carrageenan 2% on left hind paw subplantar. Irritation test were
determined using Primary Irritation Index. Data were analyzed statistically (α 0,05),
except on organoleptic and system stability. Results showed ginger oil affect
preparation organoleptic, viscosity, spreadability, and adhesion time. Cream were not
experienced phase separation. Highest antiinflammatory effect were shown by 3%
ginger oil cream. There were no irritation found on rats skin after application.
Keywords: ginger oil, preparation physical characterization, system stability,
antiinflammatory effect, irritation, chemical enhancer |
|
| dc.format |
text |
|
| dc.relation |
http://farmasi.unpad.ac.id/ispst2016/ |
|
| dc.relation |
http://eprints.ulm.ac.id/1412/ |
|
| dc.subject |
RS Pharmacy and materia medica |
|
| dc.title |
EFFECT OF GINGER OIL IN DICLOFENAC SODIUM CREAM TO
PREPARATION PHYSICAL CHARACTERIZATION, SYSTEM STABILITY,
ANTIINFLAMMATORY ACTIVITY AND IRRITATION |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|