In Silico Study Anti-Inflammatory of Active Compound of Ramania Leaves Extract (Bouea macrophylla Griffith) Against Protein Kinase C- β

Abstract

Background: Traumatic Dental Injury (TDI) causes injury to the teeth and tissues around the oral cavity. A total of 17.2% incidence of TDI in children and adolescents under the age of 18 years, in permanent teeth TDI as much as 15.2%. TDI will cause an inflammatory process that will increase the immune response. PKC-β is a conventional type of PKC isoform. Prolonged PKC-β activation is associated with impaired NF-κB activation by TNF-α. PKC-β has been shown to reduce the activity of NF-κB. PKC has a clear role in several cellular functions and diseases, making PKC isoenzymes a very promising target for drug development. TDI can be treated with herbal medicine therapy, one of the plants that can be used as medicinal plants is ramania (Bouea macrophylla Griffith). Objective : To analyze the binding of the active compound of BMG leaf extract to the expression of PKC-β as an anti- inflammatory with the in sillico method. Methods: This research is computationally based with the in sillico method. This research uses molecular docking analysis of the protein X-Ray diffreaction results from the Protein Data Bank (PDB) ID web. The Docking process is carried out using Autodock Vina which is integrated in the PyRx application and visualized using the Biovia Discovery Studio application. Conclusion : The methyl ricinoleate compound in BMG is the most potent inhibitor of Protein Kinase C-β and has the potential as an anti-inflammatory of the 10 BMG leaf extract compounds studied