Repo Dosen ULM

The effect of ethanol extract of pasak bumi (Eurycoma longifolia Jack.) on neurogenesis and neuroinflammation of rat post protein malnutrition

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dc.contributor.author Sanyoto, D D
dc.contributor.author Triawanti
dc.contributor.author Noor, M S
dc.date.accessioned 2024-06-04T06:26:51Z
dc.date.available 2024-06-04T06:26:51Z
dc.date.issued 2021
dc.identifier.issn 1755-1307
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/33789
dc.description.abstract Abstract. Protein malnutrition may affect changes in morphology, neurochemistry, neurogenesis and immune system in the brain. Pasak bumi is often used as an aphrodisiac which is almost the same as Ginseng. The neurogenesis development can be stimulated by ginseng extract intervention. This study aimed to prove the effect of pasak bumi on neurogenesis and neuroinflammation in post-protein malnutrition rats. Experimental research design, rats were divided into 6 groups: KN=normal rats+standard feed, P1=malnutrition rats+aquadest, P2=malnutrition rats + 70% ethanol extract of pasak bumi (EPB) 7.5 mg/kg BW, P3=malnutrition rats + EPB 15 mg/kg BW, P4=malnutrition rats + EPB 22.5 mg/kg BW, P5=malnutrition rats + EPB 30 mg/kg BW. EPB administration for 5 weeks. Parameters examined were levels of BDNF, IL6, TNFα, and serotonin by ELISA method. Statistical analysis using ANOVA and Kruskal Wallis test with 95% confidence level. The results of the study: the mean BDNF level in the P3 group was significantly highest (p=0.047). However, there was no significant difference between groups in IL6, TNFα, and serotonin. Conclusion: The 70% ethanol extract of pasak bumi did not affect neuroinflammation and brain serotonin levels in post-malnutrition rats, but increased BDNF levels in post-malnourished rats at a dose of 22.5 mg/kg BW en_US
dc.language.iso en en_US
dc.publisher IOP Publishing en_US
dc.relation.ispartofseries IOP Conf. Series: Earth and Environmental Science;913 (2021) 012091
dc.subject protein malnutrition, neuroinflammation, neurogenesis, Pasak bumi en_US
dc.title The effect of ethanol extract of pasak bumi (Eurycoma longifolia Jack.) on neurogenesis and neuroinflammation of rat post protein malnutrition en_US


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