Potential Antioxidant Root of Pasak Bumi (Eurycoma longifolia Jack) as Oxidative Stress Therapy in Obesity

Abstract

Abstract Background: Obesity is a chronic disease due to excess accumulation of body fat and is a major contributing factor to metabolic syndrome. In obesity, chronic inflammatory conditions occur especially in white fat which triggers oxidative stress. Many studied in obesity had proved patient with obesity have high level oxidative stress. Pasak bumi (Eurycoma longifolia Jack) is a plant that grows endemic in Indonesia, especially Kalimantan. Many studies have proven that there is a strong relationship between testosterone levels and the incidence of obesity and metabolic syndrome. Obese people have low plasma testosterone levels.7 Pasak bumi contains saponins and tannins that can reduce the absorption of dietary fat and inhibit lipogenesis activity. Pasak bumi also contains flavonoids, several studies have reported that the flavonoid content in some plants can cause adipocyte differentiation inhibitory effects and as antioxidants to solving the problem of oxidative stress in obesity. Materials and Methods: This study followed ethical consideration for animal research and had ethical approval from the ethics committee of the Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia with No.586/KEPK-FK ULM/EC/VI/2021. This study was an experimental study with posttest-only with control group design. Results: EPB doses of 7.5-22.5 mg can significantly increase SOD levels in treated mice compared to the control group, with a maximum dose of 22.5 mg/kg BW of EPB. Conclusion: EPB can reduce MDA and peroxide level in obese rats