The Effect of Pasak bumi (Eurycoma longifolia Jack) Ethanol Extract on the Lipid Profile of the Rats Was Induced High-Calorie High Fat Diet

Abstract

Abstract: Background: Obesity is often followed by hyperlipidemia which can increase morbidity and metabolic syndrome. Therapy is needed that is able to overcome not only obesity but also a metabolic syndrome that occurs. The saponin content in the pasak bumi is thought to reduce the absorption of dietary fat, tannin can inhibit the activity of lipoprotein lipase and glycerolphosphate dehydrogenase so that it can overcome hyperlipidemia. This study aims to prove the effect of ethanol extracts of pasak bumi (EPB) on the lipid profile of rats induced by a high-fat diet. Materials and Methods: The research was an experimental study. Rats were divided into 6 groups: (K0) normal mice + placebo; (K1) overweight mice + placebo (aquades); (P1) overweight mice + EPB 7.5 mg/kgBW; (P2) overweight mice + EPB 15 mg/kgBW; (P3) overweight mice + EPB 22.5 mg/kgBW; (P4) overweight mice + EPB 30 mg/kgBW. Ethanol extract of 70% pasak bumi is given for 4 weeks. Then the lipid profile is examined. Analysis of data using the Oneway Anova test with a confidence level of 95%. Results: There were significant differences in cholesterol, triglyceride, and LDL levels in the treatment group. The group given EPB 7.5 mg/kgBW had lower cholesterol and LDL levels compared to other groups, while the lowest triglyceride levels in the group given EPB was 15 mg/kgBB. There were no differences in HDL levels in all treatment groups. Conclusion: Ethanol extract pasak bumi 7.5 and 15 mg/kg body weight can reduce cholesterol, LDL, and triglyceride levels of rats induced by high-fat diets.