Effects of The Combination of Seluang Fish (Rasbora spp.) and Pasak Bumi (Eurycoma Longifolia Jack) on Systemic Inflammation and Neurotransmitter in Stunting Model Rat (Rattus Novergicus)

Abstract

Background: Stunting causes growth and development issues which are characterized by a systemic inflammatory response and neurotrans mitter disorder. Pasak Bumi (Eurycoma longifolia Jack) and seluang fish are abundant in South Kalimantan, and they are the potential to be ad junctive therapy for stunting management. Objective: To analyze the effect of Pasak Bumi extract (EPB) and selu ang fish administration in overcoming systemic inflammation and neu rotransmitter disorders in the stunting rats model. Methods: We used six groups of stunting rats: positive control (KP) group: placebo and standard diet, P1 group: 70% EPB 15 mg/kg body weight (BW) and standard diet; P2 group: DHA 1 mg/kg BW and stand ard diet; P3 group: EPB 15 mg/kg BW, DHA 1 mg/kg BW and stand ard diet; P4 group: seluang fish; P5 group: EPB 15 mg/kg BW and selu ang fish for fiveweeks; We measured levels of IL-6, TNF-α, and seroto nin. The data were analyzed by the ANOVA test with a 95% confidence interval. Results: The levels of TNF-α (p = <0.001) and serotonin (p < 0.001) were reduced significantly in the treatment groups. Conclusion: The administration of PBE and seluang fish was able to inhibit systemic inflammation and neurotransmitter dysregulation