PENGARUH KOMBINASI BUDESONIDE DAN FORMOTEROL TERHADAP KEKASARAN PERMUKAAN RESIN KOMPOSIT BIOAKTIF

Abstract

Background: The combination of budesonide and formoterol is an effective treatment for asthma. The fumaric acid contained in the combination asthma drug budesonide and formoterol affects the condition of the oral cavity, so that it becomes acidic and causes surface roughness of tooth restorations, one of which is a composite resin whose physical properties and materials have been developed, namely bioactive composite resin. Objective: To know the effect of exposure to the combination of budesonide and formoterol asthma drug 320/9μg, 640/18μg, which was soaked only in artificial saliva on the surface roughness of the composite resin. Method: This study use a sample in the form of a disc-shaped bioactive composite resin, 10mm in diameter and 2mm in thickness using ISO 4049 specifications and divided into 3 groups, namely the group exposed to the combine asthma drug budesonide and formoterol at doses of 320/9μg, 640/18μg, and the group that was immersed in artificial saliva. Result: One Way ANOVA and Post Hoc Bonferonni showed a significant difference in the roughness value of the bioactive composite resin between group exposed to the combination of budesonide and formoterol asthma drug 640/18μg and the group that was soaked only in artificial saliva. Conclusion: There is an effect of exposure to the combination of budesonide and formoterol asthma drug on the surface roughness of the bioactive composite resin.