Abstract:
Inflammatory Bowel Disease (IBD) is an inflammatory disease occurring in gastirct
tract, particularly colon, that could result from the side effect of anti-inflammatory
non-steroid (AINS) drug utilization, such asindomethacine. Mas ngur oysters
(Atactodea striata) have long been known by people of Kei-Southeast Mallucas as
traditional medicine, but its use in reducing MDA level in rat with IBD has not been
studied. This study was aimed at measuring the ability of the bioactive compounds
contained in mas ngur oyster powder extract to reduce the MDA level in the ileum
of indomethacine-induced rat with IBD and providing the histological image of the
ileum after therapized with mas ngur oyster extract. Test animals were 8-12 week
old-male rats (Rattus norvegicus) of 150 - 200 g BW. They were separated into 3
groups, healthy, sick (induced with 15 mg/kg BW indomethacine), therapy goups
(15 mg/kg BW indomethacine oral induction then treated with mas ngur oyster
powder of100, 400, 700 mg/kg BW). Indomethacine induction of 15 mg/kg BWand
therapy of mas ngur oyster powder extract were administered orally. MDA level
was measured usingThiobarbituric Acid (TBA)test and histological image of the
ileum using Hematoxylin-Eosin staining. Results showed that mas ngur extract
