Repo Dosen ULM

Turnitin Jurnal - Cytotoxicity Effect of the Pericarp Extracts of Garcinia forbesii King on MCF-7 Breast Cancer and HepG2 Liver Cancer Cell Lines

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dc.contributor.author Joharman, Joharman
dc.contributor.author Poerwono, Hadi
dc.date.accessioned 2023-04-03T05:43:14Z
dc.date.available 2023-04-03T05:43:14Z
dc.date.issued 2021-01-13
dc.identifier.isbn 10.5530/pj.2021.13.32
dc.identifier.issn 0975-3575
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/27698
dc.description.abstract Background: The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. Materials and Methods: The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer. en_US
dc.publisher Pharmacognosy Journal en_US
dc.subject Garcinia forbesii King en_US
dc.subject Cytotoxic en_US
dc.subject MCF-7 en_US
dc.subject HepG2 en_US
dc.subject Anticancer en_US
dc.title Turnitin Jurnal - Cytotoxicity Effect of the Pericarp Extracts of Garcinia forbesii King on MCF-7 Breast Cancer and HepG2 Liver Cancer Cell Lines en_US
dc.title.alternative Turnitin Jurnal - Cytotoxicity Effect of the Pericarp Extracts of Garcinia forbesii King on MCF-7 Breast Cancer and HepG2 Liver Cancer Cell Lines en_US
dc.type Book en_US


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