(Prosiding) Effect Of Coal Dust Exposure To Serum Interleukin 6 (IL6) And Vascular Endothelial Growth Factor (VEGF) Level As Preeclampsia Induction In Pregnant Rattus Novergicus

Abstract

South Kalimantan is one of provinces in Indonesia that has a lot of coal minings. south kalimantan living environtment committee showed that there are 49 coal minings in 13 regions. the most coal minings are in Kotabaru, Tanah Laut and Balangan, each has 10 coal minings. Air pollution because of coal dust can effect endothelial function, such as hypertension in pregnant or preeclampsia. One of its mechanisms is coal dust can induce inflammation. One of inflammation’s indicator is high level of IL6. Inflammation disturb angiogenesis which is showed by low level of VEGF. High inflammation and low angiogenesis can induce endothelial dysfunction which is found in preeclampsia. This research’s goal was to analyze the effect of coal dust exposure to serum IL6 and VEGF level as preeclampsia induction in pregnant rattus novergicus. The design was experimental with post test only with control group design, consisted of 7 groups: control/K0 (group without coal dust exosure), group with coal dust exposure 6,25 mg/m3 for 1 hour/day (K1-1), group with coal dust exposure 12,5 mg/m3 for 1 hour/day (K1-2), group with coal dust exposure 25 mg/m3 for 1 hour/day (K1-3), group with coal dust exposure 6,25 mg/m3 for 2 hour/day (K2-1), group with coal dust exposure 12,5 mg/m3 for 2 hour/day (K2-2), and group with coal dust exposure 25 mg/m3 for 2 hour/day (K2-3). Exposure started since first day of pregnant untill 19th day of pregnant, and termination was in the 19th of pregnant after exposure. Serum IL6 level in all of groups was in normal distribution (p value > 0,05) but not homogen (p value < 0,05), So IL6 was analyzed by nonparametric Kruskal Wallis test with p value = 0,000. It meant that there was effect of coal dust exposure to serum IL6 level as preeclampsia induction in pregnant Rattus novergicus. Serum VEGF level was not in normal distribution (p value < 0,05), so it was analyzed by nonparametric Kruskal Wallis test with p value = 0,002. It meant that there was effect of coal dust exposure to serum VEGF level as preeclampsia induction in pregnant rattus novergicus. Coal dust exposure caused high inflammation and disturb angiogenesis. So it could induce endothelial dysfunction in preeclampsia process. The conclusion was there was effect of coal dust exposure to serum IL6 and VEGF level as preeclampsia induction in pregnant Rattus novergicus.