Repo Dosen ULM

Bukti Koresponden, Measuring the potential antioxidant activity of methyl gallate: Molecular docking study

Show simple item record

dc.contributor.author Sutomo, Sutomo
dc.date.accessioned 2023-02-09T01:27:19Z
dc.date.available 2023-02-09T01:27:19Z
dc.date.issued 2020-02-12
dc.identifier.citation http://www.tjps.pharm.chula.ac.th/ojs/index.php/tjps/article/view/116 en_US
dc.identifier.issn 1905-4637
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/27110
dc.description.abstract Objectives: This study aims to obtain predictions of the interactions that occur between methyl gallate and various antioxidant receptors while comparing it with gallic acid as its parent compound. Materials and Methods: The protein crystal structures of several antioxidant receptors from several classes such as an oxidoreductase (PDB ID 1HD2, 3MNG, and 3NRZ), transferase (PDB ID 2HCK), and transport proteins (PDB ID 4JK4) were selected as receptors. Molecular docking was performed using methyl gallate and gallic acid as test ligands with AutoDock 4.2.6. The main parameters used were the free energy of binding as an affinity marker and amino acid residues to see the level of similarity of interactions. Results: Of the five receptors used, methyl gallate showed the highest potential antioxidant activity at the 3NRZ receptor (xanthine oxidase) with the free energy of binding value of −7.45 kcal/mol, with the whole receptor showing a negative value, indicating a spontaneous reaction occurs. Both the affinity and the interaction between methyl gallate and gallic acid are not too much different, meaning the potential for comparable antioxidant activity. Conclusion: Overall, methyl gallate shows the potential for the antioxidant activity that is not too different from that indicated by gallic acid. en_US
dc.language.iso en en_US
dc.publisher Thai Journal of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Chulalongkorn University en_US
dc.relation.ispartofseries 44;1
dc.subject Antioxidant, docking, gallic acid, methyl gallate, xanthine oxidase en_US
dc.title Bukti Koresponden, Measuring the potential antioxidant activity of methyl gallate: Molecular docking study en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account