EFFECT OF ARTOCARPUS ALTILIS DECOCTION UNRIPE ON ADVANCED GLYCATION END PRODUCTS IN HYPERGLICEMIA INDUCED RATS (RATTUS NORVEGIUS)

Abstract

Hyperglycemia is a condition in which an excess of sugar (glucose) circulates in the blood. Hyperglycemia promotes oxidative stress. Oxidative stress to the continuance to end the formation Advanced Glycation End Products (AGEs) that may accelerate the formation of advanced glycation and products (AGEs). The increase in AGEs formation may damage organs and tissues such a kidney, liver, brain, lung and nerve. It is also known to be an antioxidant capable of protecting cell membrane and may help prevent AGEs accumulation. This research is aimed to study the effect of decoction of unripe A.altilis on AGEs inhibitor liver of hyperglycemic male rats (Rattus norvegicus). It was a experimental study with posttest-only with control design, consisted of five groups of treatment. Group 1: control rats given only buffer; group 2: diabetic control (STZ 55mg/kg body weight of rats); group 3,4,5: diabetic rats treated with decoction of unripe A.altilis to dose of 0.266; 0.533; 1.066 mg/g body weight of rats/day/100 ml) in aqueous solution orally for 30 days. The average of AGEs level groups 1, 2, 3, 4, 5 were 0,724 (mol 1^-1), 1.128 (mol 1^-1), 0.937 (mol 1^-1), 0.805 (mol 1^-1), 1.262 (mol 1^-1), respectively. In conclusion, A.altilis decoction of unripe was capable of inhibiting AGEs formation in hyperglycemia induced rats in dose of 0.266 mg/g, and 0.533 mg/g body weight of rats in 100 ml.