SKRINING SENYAWA AKTIF DARI BALIK ANGIN A. excels (Fenzl) Benth. TERHADAP RESEPTOR TNF-alpha convertase (TACE) DENGAN METODE DOCKING

Abstract

Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that is involved in various diseases such as meningitis, rheumatism, asthma, tuberculosis, chronic periontitis, Crohn's disease, hepatitis and nasal sinusitis. So that its expression needs to be controlled to overcome this disease. The aim of this study was to screen for TNF-alpha convertase (TACE) receptor inhibitors to reduce TNF-α expression. By decreasing TNF- expression, it can act as an antiinflammatory or immunosuppressant. One of the plants that can be used for this screening is A. excels. The method used for screening is through PASSonline and Docking with PLANTS and seen the prediction of entering the blood circulation with SWISSADME. Based on PASSonline Compounds that have a high probability of immunosuppressant activity score are batulinic acid (0.724), alphitolic acid (0.763), cis-coumaroyl alphitolic acid (0.771). Meanwhile, those with antiinflammatory probability activity were batulinic acid (0.741) and cis-coumaroyl alphitolic acid (0.783). Based on the stability of the interaction, compounds that have a minimum ability of 80% against the reference ligand are alphitonin (98.25%), alphitexolide (92.33%), cis-coumaroyl alphitolic acid (98.31%). In conclusion, the compound that has the potential as an immunosuppressant, anti-inflammatory and has good interaction stability is cis-coumaroyl alphitolic acid and alphitonin. Keywords: TNF-α, A.excels, interaction. interaction