Hubungan antara Skor GCS dengan Kadar C-Reactive Protein (CRP) Pasien Cedera Otak Traumatik di IGD RSUD Ulin Banjarmasin

Abstract

Abstract Backgound and Objective: In traumatic brain injury (TBI), the level of severity could be assessed by GCS, so it is necessary to measure the GCS score to categorize the severity of TBI. TBI may followed by inflammatory mediators cell and one of inflammation marker released by liver, namely c-reactive protein (CRP).The purpose of this study is to analyze correlation between GCS scores and CRP levels in patients with traumatic brain injury at the emergency departement of Ulin General Hospital Banjarmasin. Subject and Method: This study is a analytic observational study with cross sectional design. Data acquired prospectively with consecutive sampling method in TBI patients who entered the emergency department of Ulin General Hospital in the period from July-September 2018 that fulfilled inclusion criteria and exclusion criteria. Result: We obtained 53 subjects consisted of 42 males and 11 females with a distribution of 22 (41.5%) mild TBI patients, 20 (37.7%) modarate TBI patients, and 11 (20,8%) severe TBI patients. Measurements of CRP levels were obtained at an averange of 4.64 mg/l in mild TBI, 18.00 mg/l in moderate TBI, and 26.73 mg/l in severe TBI. There was correlation between the increasing of CRP levels with severity of TBI using Kruskal-Wallis test with a confidence level of 95% (p=0.034), in Post Hoc analysis using Mann-Whitney test, there was significant differences in elevated CRP levels between moderate-severe TBI patients compared to mild TBI patients. Conclusion: It was concluded that there was a corellation between GCS scores and CRP levels in TBI patients. Key words: traumatic brain injury, c-reactive protein, glasgow coma scale (GCS)