Properties of cellulose and modified cellulose-alginate for rifampicin drug delivery

Abstract

Oral drug delivery of rifampicin as tuberculosis healing treatment has several challenging issues such as poor solubility in water and short biological half-life resulting in some unfavorable side effects. Various polymeric materials have the prospective to overcome the obstacles correlated with rifampicin oral drug delivery to deliver controlled release and protect this drug from the severe gastric environment. In this study, alginate (Alg), alginate- cellulose (Alg-Cel), and alginate-C16TMABr modified cellulose (Alg-MCel) beads were prepared and evaluated as a potential agent for drug delivery of rifampicin. Numerous parameters were investigated, such as beads size, gel fraction, swelling ratio, encapsulation efficiency, and release percentage. The results showed that the addition of cellulose and C16TMABr modified cellulose into the alginate improves the encapsulation efficiency and controlled release of rifampicin.