Repo Dosen ULM

Turnitin - Eleutherine Americana Merr. Extract Regulates Mitochondrial Calcium Homeostasis in Intra Abdominal Adhesion A Computational Study

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dc.contributor.author POERWOSUSANTA, HERY
dc.date.accessioned 2021-02-02T07:46:43Z
dc.date.available 2021-02-02T07:46:43Z
dc.date.issued 2021-01-30
dc.identifier.issn 0975-7619
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/18908
dc.description Turnitin en_US
dc.description Turnitin en_US
dc.description.abstract Aim: Intra-abdominal adhesion (IAA) is the most significant complication after surgery. This study explores the active compound from Eleutherine americana Merr. as a regulator of mitochondrial calcium homeostasis in IAA. This study aimed to evaluate computationally the potential of E. americana Merr. extract as a mitochondrial calcium activator in IAA cases. Materials and Methods: The sample was 14 active compounds from E. americana Merr. extract that was collected from the PubChem database. Prediction as a calcium channel activator was conducted using Prediction of Activity Spectra for Substances SERVER. Human intestinal absorption (HIA) and lethal dose 50 (LD50) were evaluated using SERVER. Protein target and pathway were evaluated using STITCH, and computational analysis was done using Cytoscape. Results: The results showed that 10 bioactives from E. americana Merr. extract have potential as calcium activators (Pa >0.3). The active compound of E. americana Merr. can be easily absorbed in the intestine based on its HIA+ score (HIA >0.9). Conclusion: The application of this extract was possible due to LD50 evaluation that showed that it was less toxic (LD50 <3 mol/kg-BW). E. americana Merr. extract regulates mitochondrial calcium homeostasis, by modulation of two types of the mitochondrial calcium channels, VDAC1 and MARCK (mRyR). KEY WORDS: Calcium activator, Eleutherine americana Merr., MARCK, VDAC1 en_US
dc.description.abstract Aim: Intra-abdominal adhesion (IAA) is the most significant complication after surgery. This study explores the active compound from Eleutherine americana Merr. as a regulator of mitochondrial calcium homeostasis in IAA. This study aimed to evaluate computationally the potential of E. americana Merr. extract as a mitochondrial calcium activator in IAA cases. Materials and Methods: The sample was 14 active compounds from E. americana Merr. extract that was collected from the PubChem database. Prediction as a calcium channel activator was conducted using Prediction of Activity Spectra for Substances SERVER. Human intestinal absorption (HIA) and lethal dose 50 (LD50) were evaluated using SERVER. Protein target and pathway were evaluated using STITCH, and computational analysis was done using Cytoscape. Results: The results showed that 10 bioactives from E. americana Merr. extract have potential as calcium activators (Pa >0.3). The active compound of E. americana Merr. can be easily absorbed in the intestine based on its HIA+ score (HIA >0.9). Conclusion: The application of this extract was possible due to LD50 evaluation that showed that it was less toxic (LD50 <3 mol/kg-BW). E. americana Merr. extract regulates mitochondrial calcium homeostasis, by modulation of two types of the mitochondrial calcium channels, VDAC1 and MARCK (mRyR). KEY WORDS: Calcium activator, Eleutherine americana Merr., MARCK, VDAC1 en_US
dc.publisher JPR Solutions en_US
dc.subject Turnitin en_US
dc.subject Turnitin en_US
dc.title Turnitin - Eleutherine Americana Merr. Extract Regulates Mitochondrial Calcium Homeostasis in Intra Abdominal Adhesion A Computational Study en_US
dc.type Article en_US


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