Repo Dosen ULM

Dayak Onions (eleutherine Americana L Merr) Reduced Mesothelial Detachment After Laparoscopic

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dc.contributor.author POERWOSUSANTA, HERY
dc.date.accessioned 2021-01-04T02:25:20Z
dc.date.available 2021-01-04T02:25:20Z
dc.date.issued 2020-11-16
dc.identifier.other 000179019
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/18682
dc.description Peer Review en_US
dc.description.abstract Background: Laparoscopy induces mesothelial structure changes and detachment. The studies about preventing the mesothelial cell detachment were rarely found. Dayak tribe uses the Dayak onion (Eleutherine americana L. Merr) as a wound-healing agent due to its anti-inflammatory and antioxidant activity. This study aimed to prove the anti-inflammatory and antioxidant activity of Dayak onion to prevent mesothelial cells damage after laparoscopy. Methods: Thirty males Sprague-Dawley Rattus norvegicus were divided into five groups (n = 6 per group): (a) control, (b) mediclor, (c) Dayak onion 30 mg/kg, (d) Dayak onion 60 mg/kg, and (e) Dayak onion 90 mg/kg body weight. Transforming growth factor-beta (TGF-β) and total oxidant status (TOS/H2O2) from peritoneal fluid was determined 24 h after laparoscopy. Histopathological analysis of mesothelial cell numbers in the peritoneum, small intestine, greater omentum, and liver was performed 7 days after the procedure. Results: In-silico analysis result suggested one of the Dayak onions’ active compounds, eleutherine, has a potential activity as an anti-inflammatory and modulator of TGF-β. Also, the TGF-β level, the number of mesothelial cells detachment, and ZO-1 expression were significantly decreased following Dayak onion administration (p<0.05). Conclusions: Our study showed that Dayak onion administration in rats reduced TGF-β level, number of mesothelial cells detachment, and ZO-1 expression following laparoscopy. en_US
dc.publisher Fakultas Kedokteran ULM en_US
dc.subject Peer Review en_US
dc.title Dayak Onions (eleutherine Americana L Merr) Reduced Mesothelial Detachment After Laparoscopic en_US
dc.type Other en_US


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