Peer Review : Pengaruh Pajanan Logam Kadmium (Cd) terhadap Kadar Kalsium (Ca) dan Kadar Fosfat pada Tikus Putih (Rattus novergicus)

Abstract

This study aimed to analyze the longexposure to Cadmium (Cd) on the levels of calcium andphosphate bone white mice. This study uses a white rat bone exposed and unexposed Cd were24 male rats were divided into 4 groups for 0, 2, 4 and 6 weeks. After the surgery and thenmeasured levels ofcalcium and phosphate bone white mice.The results showed that therewere significant differences in the levels of Ca between control and treatment groups. Whiterat bone Ca levels decreased respectively 118,067mg/gramof bone; 87,267mg/gramof bone;39,667mg/gramof bone and 13,067mg/grambone at weeks 0, 2, 4 and 6. The results ofstatistical tests performedby Kruskal-Wallis (p=0.000; p<0.05), it is stated that long exposureto Cd can significantly reduce levels of Ca in the bones of mice. This happens due to adecrease in absorption in the intestine Cd Cd compete with, so that the levels of Ca in bonesdecreased.In addition the research also showed levels of phosphate bone consecutive weeks0, 2, 4 and 6 is equal to 335,583mg/L; 258,583mg/L; 251,833mg/Land 208,667mg/L.Results of statistical tests performed byKruskal-Wallis (p=0.116; p>0.05), which means thatexposure to Cd can not lower phosphate levels significantly due to the reciprocal relationshipbetween Ca and P which resulted in secretion of parathyroid hormone so the bone does notrelease phosphate in the number of great. Thus concluded that exposure to heavy metalscadmium (Cd) for 6 weeks can reduce bone calcium white mice, but have not been able toreduce levels of phosphate bone white mice significantly.