Urine Protein, Creatinine, and Uacr Level in Pregnant Mus Musculus Injected by Anti Qa2 as Endothelial Dysfunction Model to Induce Preeclampsia

Abstract

Preeclampsia is a condition which was identified by diastol blood pressure ≥ 90 mmHg in 20 weeks of pregnant, and blood pressure in < 20 weeks of pregnant was still < 90 mmHg. Beside hypertension, we also find proteinuria in preeclampsia after 20 weeks of pregnant. Preeclampsia could cause low renal function that was indicated by creatinine and UACR level. Preeclampsia happened from endothelial dysfunction. Endothelial dysfunction in Mus musculus could be made by injecting anti QA2. This research was to analyze urine protein, creatinine, and UACR level in endthelial dysfunction model in pregnant Mus musculus. The result was dose of anti QA2 could cause the increasing of urine protein and UACR level, but not to urine creatinine level. The conclusions were there was significant differences of urine and UACR protein level in pregnant Mus musculus that was injected by anti QA an endothel dysfunction model that induced preeclampsia, but not to urine creatinine level. The suggestions were preeclampsia must be detected, prevented and treated as soos as possible, to prevent mechanism of endothel dysfuncyion in preeclampsia that could cause low renal function.