Abstract:
Endosulfan is a forbidden insecticide that may cause some nerve related disorders. Some oxidative stress
and inflammation markers may play a role in these neurotoxic events. This study aimed to analyze the effect
of endosulfan exposure in white rat pup’s brain in pregnant rat model. This study used pregnant white rats
induced by endosulfan administered orally and divided to endosulfan treatment and control. After the
female rats gave birth, endosulfan treatment was stopped. The pups were left to suckle on their mothers.
When the pups had reached four weeks, 16 pups were terminated and brains were taken from each group
were taken to examine levels of MDA, SOD, H2O2, AOPP, TNF-α, and Hsp70. The data collected were
analyzed using Student's T-test or Mann-Whitney U test. The results suggested that MDA, H2O2, AOPP and
TNF-α levels were higher in endosulfan group compared to control group (p<0.05), SOD levels decrease in
endosulfan group (p<0.05) and no significant difference in Hsp70 levels between the group. This study
concluded that endosulfan interfered the oxidative stress and inflammatory markers of pup’s brain induced
by endosulfan in the pregnant rat model.
