Repo Dosen ULM

The changes in placental IL-10 level, placental IFN-γ level, and placental VCAM-1 expression in endothelial dysfunction model using Mus musculus which had mild regular exercise

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dc.contributor.author Syahadatina Noor, Meitria
dc.contributor.author Santoso, Budi
dc.contributor.author Triawanti, Triawanti
dc.contributor.author Widjiati, Widjiati
dc.date.accessioned 2020-09-01T02:09:20Z
dc.date.available 2020-09-01T02:09:20Z
dc.date.issued 2018-01-09
dc.identifier.other https://doi.org/10.1177/1721727X18757378
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/17739
dc.description.abstract Preeclampsia is a syndrome that consists of hypertension (blood pressure ⩾ 140/⩾ 90 mm Hg) and proteinuria (⩾ 0.3 g/24 h). It occurs after 20 weeks of gestation. Preeclampsia and eclampsia are the causes of maternal mortality in Indonesia. Hypertension is the second cause of maternal mortality in Indonesia after hemorrhage. The mechanism of preeclampsia might occur through inflammation process that would cause endothelial dysfunction. Preeclampsia leads to complications both in the mother and the fetus. The effective management for preeclampsia is prevention, including mild regular exercise since early pregnancy. This research objective was to analyze the inflammation process and endothelial dysfunction in an endothelial dysfunction model using mice who had mild regular exercise since early pregnancy. There were three treatment groups with 14 mice each, namely, normal pregnancy group (K1), endothelial dysfunction group (K2), and endothelial dysfunction group with mild regular exercise since early pregnancy (K3). The mice in K3 group had mild regular exercise by doing a treadmill for 18 min once every 2 days. The results showed that the placental interleukin 10 (IL-10) level in K3 was lower than that in K2 (599.86 vs 636.36, P = 0.001), the placental interferon gamma (IFN-γ) level in K3 was higher than that in K2 (322.36 vs 299.50, P = 0.002), and the placental vascular cell adhesion molecule 1 (VCAM-1) expression in K3 was higher than that in K2 (5.33 vs 1.67, P = 0.000). It can be concluded that mild regular exercise since early pregnancy did not decrease the inflammation process and the expression of placental VCAM-1 in endothelial dysfunction model using mice. en_US
dc.language.iso en en_US
dc.publisher European Journal of Inflammation en_US
dc.subject endothelial dysfunction en_US
dc.subject mild regular exercise en_US
dc.subject placental inflammation en_US
dc.subject preeclampsia en_US
dc.title The changes in placental IL-10 level, placental IFN-γ level, and placental VCAM-1 expression in endothelial dysfunction model using Mus musculus which had mild regular exercise en_US
dc.type Article en_US


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