Oxidative Stress and Inflammation Marker Profiles of White Rat Pup’s Brain Endosulfan-induced Neurotoxicity in Pregnant Rat Model

Abstract

Abstract: Endosulfan is a forbidden insecticide that may cause some nerve related disorders. Some oxidative stress and inflammation markers may play a role in these neurotoxic events. This study aimed to analyze the effect of endosulfan exposure in white rat pup’s brain in pregnant rat model. This study used pregnant white rats induced by endosulfan administered orally and divided to endosulfan treatment and control. After the female rats gave birth, endosulfan treatment was stopped. The pups were left to suckle on their mothers. When the pups had reached four weeks, 16 pups were terminated and brains were taken from each group were taken to examine levels of MDA, SOD, H2O2, AOPP, TNF-α, and Hsp70. The data collected were analyzed using Student's T-test or Mann-Whitney U test. The results suggested that MDA, H2O2, AOPP and TNF-α levels were higher in endosulfan group compared to control group (p<0.05), SOD levels decrease in endosulfan group (p<0.05) and no significant difference in Hsp70 levels between the group. This study concluded that endosulfan interfered the oxidative stress and inflammatory markers of pup’s brain induced by endosulfan in the pregnant rat model.