Number of foetus in pregnant Mus musculus which was injected by anti Qa2 and given mild regular exercise: endothelial dysfunction animal model to induce preeclampsia

Abstract

Preeclampsia community guidline (PRECOG) defined preeclampsia as a condition which was identified by the diastol blood pressure ≥ 90 mmHg and proteinuria in ≥ 20 weeks of pregnant. Basic mechanism of preeclampsia was endothelial dysfunction. One of preeclampsia’s impacts was intra uterine fetal death. It could be signed by less number of foetus. One of ways to prevent preeclampsia’s process was mild regular exercise. This research’s goal was analyzing the effect of mild regular exercise to number of foetus in pregnant Mus musculus which was injected by anti QA2 as endothelial dysfunction animal model to induce preeclampsia. The design was experimental. It used 6 Mus musculus/group. The groups were control (normal pregnant/K1), pregnant Mus musculus which was injected by anti QA2 (endithelial dysfunction model/K2), pregnant Mus musculus which was injected by anti QA2 and given mild regular exercise since early pregnant (K3), and pregnant Mus musculus which was injected by anti QA2 and given mild regular exercise since 1 week before pregnant (K4). Statistical analyze used Kruskal Wallis Test (α=0,05). It showed there was no significant different of foetus’ number among all groups. The conclussion was there was no effect of mild regular exercise to number of foetus in pregnant Mus musculus which was injected by anti QA2 as endothelial dysfunction animal model to induce preeclampsia.