Repo Dosen ULM

Swallow nest extract can be able to prevent nephropathy diabetic of the white rats streptozotocin-induced

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dc.contributor.author Triawanti, Triawanti
dc.contributor.author Alexandra, F D
dc.contributor.author Frethernity, A
dc.contributor.author Mahmud, S
dc.date.accessioned 2020-09-01T02:08:31Z
dc.date.available 2020-09-01T02:08:31Z
dc.date.issued 2019-10-22
dc.identifier.other doi:10.1088/1742-6596/1374/1/012050
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/17728
dc.description.abstract Hyperglycemia that occurs in diabetic mellitus leads to glycation reactions in protein molecules and oxidative stress resulting in damage to cells and organs. Swallow nest believed society can lower blood glucose. The objective of the study was to analyze the potency of water swallow nest extract to prevent nephrophaty diabetic. The study used Post test-Only with Control Group Design, which consisted of 1 control group (K = aquadest) and 3 treatment groups (nest swallow nest dose 1, 10 and 100 mg / kg BW) each group consisted of 6 Rattus Norvegicius. Before treatment, means of glucose level rats have been 68 mg/DL, then rats were induced Streptozotocin in a dose of 40 mg / kg BW intraperitoneally. Day 7th after induction, rats had elevated glucose ± 102 - 108 mg / dL. Then the rats were given water extract nest swallow white for 28 days orally. All data were analyzed by Kruskall-Wallis test followed by Mann-Whitney test with 95% confidence level. The results of blood glucose levels in each group (K, P1, P2 and P3) were 111.0 vs 88.5 vs 86 vs 83 mg / dL (p = 0.004), pancreas H2O2 levels were 10.16 vs 9.20 vs 8.81 vs 7.27 (p=0,000), serum H2O2 levels were 17.35 vs 16.39 vs 15.01 vs 11.96 (p=0.044), renal methylglioxal levels were 242.55 vs 134.34 vs 67.12 vs 50.48% (p = 0,000) and renal AOPP levels were 1.17 vs 1.09 vs 1.05 vs 1.00 (p=0.000) respectively. The Mann-Whitney test showed a dose of 100 mg / kgBW has the greatest potential. In conclusion the swallow nest water extract has potential as an antidiabetic and prevent of renal’s damage. en_US
dc.language.iso en en_US
dc.publisher ResourcesJournal of Physics: Conference Series en_US
dc.subject Swallow Nest (Collocalia fuciphaga) en_US
dc.subject Water Extract en_US
dc.subject hyperglycemia en_US
dc.subject oxidative stress en_US
dc.subject nephropathy diabetic en_US
dc.title Swallow nest extract can be able to prevent nephropathy diabetic of the white rats streptozotocin-induced en_US
dc.type Article en_US


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